This research introduces advanced patient simulators using large language models to improve the critical connection between medical inquiry and diagnostic accuracy in online consultations.

• Addresses the overlooked inquiry phase in medical consultations, not just diagnostic outcomes
• Demonstrates limitations of simple prompt engineering for accurate patient simulation
• Proposes new paradigms for creating more realistic virtual patients
• Establishes frameworks for evaluating the quality of doctor-patient interactions

This innovation matters because it could transform medical education, telemedicine practices, and improve diagnostic workflows by creating more realistic training scenarios for healthcare professionals.

Exploring the Inquiry-Diagnosis Relationship with Advanced Patient Simulators