HybriDNA introduces a novel hybrid architecture that significantly improves DNA modeling by combining the strengths of Transformers and Mamba2 to process ultra-long DNA sequences while maintaining single-nucleotide resolution.

• Achieves state-of-the-art performance on DNA understanding and generation tasks
• Handles sequences up to 1 million nucleotides long while preserving critical single-nucleotide precision
• Balances efficient computation with high accuracy through its innovative hybrid design
• Enables breakthroughs in genomic research with applications for disease understanding and biological mechanism discovery

This research represents a significant advancement for computational biology by providing powerful tools to decode the 'language of life,' potentially accelerating discoveries in genetic research and personalized medicine.

HybriDNA: A Hybrid Transformer-Mamba2 Long-Range DNA Language Model