AMP-Designer uses large language models to rapidly design novel antimicrobial peptides with specific properties, achieving remarkable results in just 11 days.

• Developed 18 novel antimicrobial peptides with broad-spectrum activity against Gram-negative bacteria
• Achieved a 94.4% success rate in laboratory validation
• Completed the entire discovery process in only 11 days
• Demonstrated efficacy in murine lung infection experiments

This research represents a significant advancement for combating antibiotic resistance, potentially accelerating the development of new treatments for bacterial infections at a time when antimicrobial resistance poses a growing global health threat.

Discovery of novel antimicrobial peptides with notable antibacterial potency by a LLM-based foundation model