Prot42 introduces a novel family of protein language models that generate functional protein binders without requiring target protein 3D structures or binding site information.

• Overcomes limitations of conventional protein engineering methods that are complex and resource-intensive
• Generates high-affinity protein binders using only sequence information
• Demonstrates effectiveness for creating DNA-binding proteins and therapeutic applications
• Represents a significant advancement for biotechnology and pharmaceutical development

This research enables faster, more accessible protein design workflows for therapeutic innovation and biotechnology applications, potentially accelerating drug discovery and protein-based treatment development.

Prot42: a Novel Family of Protein Language Models for Target-aware Protein Binder Generation